DCLK2 Antibody - #DF3349
| 製品: | DCLK2 Antibody |
| カタログ: | DF3349 |
| タンパク質の説明: | Rabbit polyclonal antibody to DCLK2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 83 KD; 84kD(Calculated). |
| ユニプロット: | Q8N568 |
| RRID: | AB_2835716 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3349, RRID:AB_2835716.
折りたたみ／展開
CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; DCAMK L2; DCAMKL 2; DCDC 3; DCDC 3B; DCDC3; DCDC3B; DCK 2; DCK2; DCLK 2; Dclk2; DCLK2_HUMAN; DKFZp761I032; Doublecortin and CaM kinase like 2; Doublecortin domain-containing protein 3B; Doublecortin like and CAM kinase like 2; Doublecortin like kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; MGC45428; Serine/threonine protein kinase DCLK2; Serine/threonine-protein kinase DCLK2;
免疫原
- Q8N568 DCLK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N568 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| T173 | Phosphorylation | Uniprot | |
| S182 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| S682 | Phosphorylation | Uniprot | |
| T685 | Phosphorylation | Uniprot |
研究背景
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
Autophosphorylated.
Cytoplasm>Cytoskeleton.
Note: Colocalizes with microtubules.
Expressed in the brain, heart and eyes.
Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
The doublecortin domains are involved in the colocalization with microtubules.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
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