AZI2 Antibody - #DF3437
| 製品: | AZI2 Antibody |
| カタログ: | DF3437 |
| タンパク質の説明: | Rabbit polyclonal antibody to AZI2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig |
| 分子量: | 48 KD; 45kD(Calculated). |
| ユニプロット: | Q9H6S1 |
| RRID: | AB_2835737 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3437, RRID:AB_2835737.
折りたたみ／展開
5 azacytidine induced protein 2; 5-azacytidine-induced protein 2; AA410145; AZ2; AZI2; AZI2_HUMAN; MGC112644; Nak associated protein 1; Nak-associated protein 1; NAP1; NF kappa B activating kinase associated protein 1; NF-kappa-B-activating kinase-associated protein 1; TILP; TILP(S);
免疫原
- Q9H6S1 AZI2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H6S1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S83 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| T140 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot |
研究背景
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
Cytoplasm.
Widely expressed. Abundant expression seen in the pancreas and testis.
Homodimer (By similarity). Interacts with IKBKE. Interacts with TBK1. Interacts with TICAM1.
(Microbial infection) Interacts with vaccinia virus protein C6.
研究領域
· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway. (View pathway)
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