BCOR Antibody - #DF3520
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3520, RRID:AB_2835740.
折りたたみ／展開
5830466J11Rik; 8430401K06Rik; ANOP 2; ANOP2; BCL 6 co repressor; BCL 6 corepressor; BCL 6 interacting corepressor; BCL-6 corepressor; BCL6 co repressor; BCL6 corepressor; BCL6 interacting corepressor; BCoR; BCOR_HUMAN; FLJ20285; FLJ38041; KIAA1575; MAA 2; MAA2; MCOPS 2; MCOPS2; MGC131961; MGC71031;
免疫原
- Q6W2J9 BCOR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHPSDLASDNYW
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6W2J9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K30 | Ubiquitination | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| T106 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| T128 | Phosphorylation | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| R188 | Methylation | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| R243 | Methylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| R338 | Methylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| R342 | Methylation | Uniprot | |
| Y361 | Phosphorylation | Uniprot | |
| S365 | O-Glycosylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| K374 | Acetylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| K392 | Acetylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K460 | Ubiquitination | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| K530 | Sumoylation | Uniprot | |
| K530 | Ubiquitination | Uniprot | |
| T555 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| T604 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| R647 | Methylation | Uniprot | |
| R655 | Methylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| S765 | Phosphorylation | Uniprot | |
| K774 | Ubiquitination | Uniprot | |
| K786 | Sumoylation | Uniprot | |
| K786 | Ubiquitination | Uniprot | |
| K795 | Acetylation | Uniprot | |
| K795 | Ubiquitination | Uniprot | |
| K802 | Acetylation | Uniprot | |
| K816 | Acetylation | Uniprot | |
| K823 | Acetylation | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| K839 | Ubiquitination | Uniprot | |
| K872 | Ubiquitination | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| K889 | Ubiquitination | Uniprot | |
| T917 | Phosphorylation | Uniprot | |
| S928 | Phosphorylation | Uniprot | |
| S932 | Phosphorylation | Uniprot | |
| T936 | Phosphorylation | Uniprot | |
| Y972 | Phosphorylation | Uniprot | |
| Y985 | Phosphorylation | Uniprot | |
| K1029 | Ubiquitination | Uniprot | |
| K1045 | Ubiquitination | Uniprot | |
| S1047 | Phosphorylation | Uniprot | |
| S1064 | Phosphorylation | Uniprot | |
| K1104 | Ubiquitination | Uniprot | |
| S1122 | Phosphorylation | Uniprot | |
| S1127 | Phosphorylation | Uniprot | |
| T1129 | Phosphorylation | Uniprot | |
| S1139 | Phosphorylation | Uniprot | |
| S1142 | Phosphorylation | Uniprot | |
| S1143 | Phosphorylation | Uniprot | |
| T1145 | Phosphorylation | Uniprot | |
| T1147 | Phosphorylation | Uniprot | |
| T1148 | Phosphorylation | Uniprot | |
| S1166 | Phosphorylation | Uniprot | |
| S1223 | Phosphorylation | Uniprot | |
| S1269 | Phosphorylation | Uniprot | |
| S1271 | Phosphorylation | Uniprot | |
| S1278 | Phosphorylation | Uniprot | |
| S1288 | Phosphorylation | Uniprot | |
| S1290 | Phosphorylation | Uniprot | |
| K1304 | Acetylation | Uniprot | |
| K1323 | Methylation | Uniprot | |
| K1325 | Methylation | Uniprot | |
| K1329 | Ubiquitination | Uniprot | |
| K1349 | Ubiquitination | Uniprot | |
| K1366 | Ubiquitination | Uniprot | |
| S1404 | Phosphorylation | Uniprot | |
| S1405 | Phosphorylation | Uniprot | |
| S1410 | Phosphorylation | Uniprot | |
| K1460 | Sumoylation | Uniprot | |
| K1460 | Ubiquitination | Uniprot | |
| Y1519 | Phosphorylation | Uniprot | |
| S1526 | Phosphorylation | Uniprot | |
| T1531 | Phosphorylation | Uniprot |
研究背景
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Nucleus.
Ubiquitously expressed.
Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1. Interacts with CPNE4 (via VWFA domain) (By similarity). Isoform 1 may interact with MLLT3/AF9 (By similarity).
Belongs to the BCOR family.
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