GRK7 Antibody - #DF3370
| 製品: | GRK7 Antibody |
| カタログ: | DF3370 |
| タンパク質の説明: | Rabbit polyclonal antibody to GRK7 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 62 KD; 62kD(Calculated). |
| ユニプロット: | Q8WTQ7 |
| RRID: | AB_2835752 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3370, RRID:AB_2835752.
折りたたみ／展開
G protein coupled receptor kinase 7; G protein coupled receptor kinase GRK7; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7; GPRK 7; GPRK7; GRK 7; GRK7; GRK7_HUMAN;
免疫原
- Q8WTQ7 GRK7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WTQ7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S36 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| T85 | Phosphorylation | Uniprot | |
| K229 | Acetylation | Uniprot | |
| K230 | Acetylation | Uniprot | |
| K234 | Acetylation | Uniprot | |
| K433 | Acetylation | Uniprot | |
| S490 | Phosphorylation | Q8WTQ7 (GRK7) | Uniprot |
研究背景
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
Membrane>Lipid-anchor.
Retinal cones, outer and inner segments.
Interacts (when prenylated) with PDE6D; this promotes release from membranes.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Phototransduction.
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