製品: IP3KC Antibody
カタログ: DF3397
タンパク質の説明: Rabbit polyclonal antibody to IP3KC
アプリケーション: WB IF/ICC
反応性: Human
予測: Rabbit
分子量: 102 KD; 75kD(Calculated).
ユニプロット: Q96DU7
RRID: AB_2835779

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Rabbit(82%)
クローナリティ:
Polyclonal
特異性:
IP3KC Antibody detects endogenous levels of total IP3KC.
RRID:
AB_2835779
引用形式: Affinity Biosciences Cat# DF3397, RRID:AB_2835779.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

4; 5-trisphosphate 3-kinase C; Inositol 1; inositol 1,4,5 trisphosphate 3 kinase C; Inositol trisphosphate 3 kinase C; Inositol-trisphosphate 3-kinase C; InsP 3 kinase C; InsP 3-kinase C; IP3 3-kinase C; IP3 3KC; IP3K C; IP3KC; IP3KC_HUMAN; Itpkc;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q96DU7 IP3KC_HUMAN:

Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.

タンパク質配列:
MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
82
Pig
75
Dog
75
Bovine
58
Sheep
58
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96DU7 基板として

Site PTM Type Enzyme
R7 Methylation
S9 Phosphorylation
R30 Methylation
S84 Phosphorylation
S127 Phosphorylation
S190 Phosphorylation
K224 Ubiquitination
S322 Phosphorylation
T333 Phosphorylation
T336 Phosphorylation
S348 Phosphorylation
S378 Phosphorylation
Y398 Phosphorylation
S404 Phosphorylation
Y456 Phosphorylation
Y457 Phosphorylation
K499 Ubiquitination
T566 Phosphorylation
K569 Ubiquitination
K579 Ubiquitination

研究背景

機能:

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.

細胞の位置付け:

Nucleus. Cytoplasm.
Note: Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.

タンパク質ファミリー:

Belongs to the inositol phosphokinase (IPK) family.

研究領域

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.

· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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