RPS6KC1 Antibody - #DF3408
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3408, RRID:AB_2835790.
折りたたみ／展開
52 kDa ribosomal protein S6 kinase; humS6PKh1; KS6C1_HUMAN; Ribosomal protein S6 kinase 52kD polypeptide 1; Ribosomal protein S6 kinase 52kDa polypeptide 1; Ribosomal protein S6 kinase C1; Ribosomal protein S6 kinase delta 1; Ribosomal protein S6 kinase delta-1; Ribosomal S6 kinase like protein with two PSK domains 118 kDa protein; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; RPK 118; RPK118; RPS6KC1; RSKL1; S6K-delta-1; S6PKh1; SPHK1 binding protein; SPHK1-binding protein;
免疫原
Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
- Q96S38 KS6C1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96S38 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T93 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| Y266 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| T437 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| K571 | Ubiquitination | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| K606 | Ubiquitination | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| Y622 | Phosphorylation | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S648 | Phosphorylation | Uniprot | |
| K651 | Ubiquitination | Uniprot | |
| T659 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| K674 | Ubiquitination | Uniprot | |
| S682 | Phosphorylation | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| S823 | Phosphorylation | Uniprot | |
| S826 | Phosphorylation | Uniprot | |
| S834 | Phosphorylation | Uniprot | |
| K855 | Ubiquitination | Uniprot | |
| S866 | Phosphorylation | Uniprot | |
| K869 | Ubiquitination | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| K891 | Ubiquitination | Uniprot |
研究背景
May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes.
Cytoplasm. Membrane. Early endosome.
Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
Interacts with SPHK1 and phosphatidylinositol 3-phosphate. Interacts (via PX domain) with PRDX3.
The PX domain is essential for its localization to the early endosomes.
The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
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