MED24 Antibody - #AF0346
(2)
(1)
| 製品: | MED24 Antibody |
| カタログ: | AF0346 |
| タンパク質の説明: | Rabbit polyclonal antibody to MED24 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 110kDa; 110kD(Calculated). |
| ユニプロット: | O75448 |
| RRID: | AB_2833516 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0346, RRID:AB_2833516.
折りたたみ／展開
CRSP complex subunit 4; Activator recruited cofactor 100 kDa component; Activator-recruited cofactor 100 kDa component; ARC100; Cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; CRSP100; CRSP4; DRIP100; hTRAP100; KIAA0130; MED 24; MED24; MED24_HUMAN; Mediator complex subunit 24; Mediator of RNA polymerase II transcription subunit 24; Mediator of RNA polymerase II transcription subunit 24 homolog; MGC8748; OTTHUMP00000164458; OTTHUMP00000164460; THRAP4; Thyroid hormone receptor associated protein 4; Thyroid hormone receptor associated protein complex 100 kDa component; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100; Trapp100; Vitamin D3 receptor interacting protein complex component DRIP100; Vitamin D3 receptor-interacting protein complex 100 kDa component;
免疫原
- O75448 MED24_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75448 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T36 | Phosphorylation | Uniprot | |
| Y66 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| T172 | Phosphorylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T423 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| K460 | Ubiquitination | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| K638 | Ubiquitination | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| T655 | Phosphorylation | Uniprot | |
| K717 | Ubiquitination | Uniprot | |
| K721 | Ubiquitination | Uniprot | |
| K856 | Ubiquitination | Uniprot | |
| S862 | Phosphorylation | Uniprot | |
| S863 | Phosphorylation | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| S873 | Phosphorylation | Uniprot | |
| T875 | Phosphorylation | Uniprot | |
| K965 | Ubiquitination | Uniprot | |
| T971 | Phosphorylation | Uniprot | |
| K984 | Ubiquitination | Uniprot |
研究背景
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Nucleus.
Ubiquitous. Abundant in skeletal muscle, heart and placenta.
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.
Belongs to the Mediator complex subunit 24 family.
研究領域
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
参考文献
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