DCP1A Antibody - #DF3443
| 製品: | DCP1A Antibody |
| カタログ: | DF3443 |
| タンパク質の説明: | Rabbit polyclonal antibody to DCP1A |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 75 KD; 63kD(Calculated). |
| ユニプロット: | Q9NPI6 |
| RRID: | AB_2835809 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3443, RRID:AB_2835809.
折りたたみ／展開
DCP1 decapping enzyme homolog A; Dcp1a; DCP1A_HUMAN; Decapping enzyme hDcp1a; Decapping mRNA 1A; HSA275986; mRNA decapping enzyme 1A; mRNA-decapping enzyme 1A; Nbla00360; Putative protein product of Nbla00360; Smad4 interacting transcriptional co activator; Smad4-interacting transcriptional co-activator; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF;
免疫原
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
- Q9NPI6 DCP1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NPI6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S12 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| Y64 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| Y310 | Phosphorylation | Uniprot | |
| T311 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | P45983 (MAPK8) | Uniprot |
| S319 | Phosphorylation | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T340 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| T347 | Phosphorylation | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| R376 | Methylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| T528 | Phosphorylation | Uniprot | |
| T531 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Cytoplasm>P-body. Nucleus.
Note: Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1. Interacts with NBDY.
Belongs to the DCP1 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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