Mlx Antibody - #DF3466
| 製品: | Mlx Antibody |
| カタログ: | DF3466 |
| タンパク質の説明: | Rabbit polyclonal antibody to Mlx |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 33 KD; 33kD(Calculated). |
| ユニプロット: | Q9UH92 |
| RRID: | AB_2835830 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3466, RRID:AB_2835830.
折りたたみ／展開
bHLHd13; BigMax protein; Class D basic helix-loop-helix protein 13; MAD7; Max like bHLHZip protein; Max like protein X; Max-like bHLHZip protein; Max-like protein X; MLX; MLX_HUMAN; MLXIP; MONDOA; MXD7; Protein BigMax; Protein Mlx; TCFL4; transcription factor like 4; Transcription factor like protein 4; Transcription factor-like protein 4;
免疫原
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
- Q9UH92 MLX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UH92 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| R26 | Methylation | Uniprot | |
| R29 | Methylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| T206 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot |
研究背景
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Cytoplasm.
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Cytoplasm.
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Nucleus.
Note: Found predominantly in the nucleus (PubMed:10918583).
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
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