製品: CDH19 Antibody
カタログ: DF3528
タンパク質の説明: Rabbit polyclonal antibody to CDH19
アプリケーション: WB IF/ICC
反応性: Human
予測: Bovine, Sheep, Dog
分子量: 87 KD; 87kD(Calculated).
ユニプロット: Q9H159
RRID: AB_2835882

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Bovine(89%), Sheep(89%), Dog(89%)
クローナリティ:
Polyclonal
特異性:
CDH19 Antibody detects endogenous levels of total CDH19.
RRID:
AB_2835882
引用形式: Affinity Biosciences Cat# DF3528, RRID:AB_2835882.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

CAD19_HUMAN; Cadherin 19, type 2; Cadherin-19; CDH 19; CDH19; CDH7; CDH7L2; PRO941; UNQ478;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9H159 CAD19_HUMAN:

Expressed in many tissues, with the exception of uterus.

タンパク質配列:
MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
89
Sheep
89
Dog
89
Rabbit
78
Pig
75
Horse
75
Xenopus
63
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H159 基板として

Site PTM Type Enzyme
Y4 Phosphorylation
S111 Phosphorylation
Y113 Phosphorylation
S402 Phosphorylation
S407 Phosphorylation
T409 Phosphorylation
K623 Acetylation
K630 Acetylation
K630 Ubiquitination
S631 Phosphorylation
S685 Phosphorylation
S692 Phosphorylation

研究背景

機能:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in many tissues, with the exception of uterus.

タンパク質ファミリー:

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

参考文献

1). Identification and preliminary analysis of hub genes associated with bladder cancer progression by comprehensive bioinformatics analysis. Scientific reports, 2024 (PubMed: 38307969) [IF=3.8]

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