CADM3 Antibody - #DF3537
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3537, RRID:AB_2835910.
折りたたみ／展開
BIgR; Brain immunoglobulin receptor; CADM 3; cadm3; CADM3_HUMAN; Cell adhesion molecule 3; Dendritic cell nectin like protein 1 short isoform; FLJ10698; IgSF4B; Immunoglobulin superfamily member 4B; Necl 1; Necl-1; NECL1; Nectin like 1; Nectin like protein 1; Nectin-like protein 1; Synaptic cell adhesion molecule 3; synCAM3; TSLC1 like 1; TSLC1 like protein 1; TSLC1-like protein 1; TSLL1;
免疫原
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
- Q8N126 CADM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N126 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T187 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| N290 | N-Glycosylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot |
研究背景
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
Cell membrane>Single-pass type I membrane protein. Cell junction.
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).
The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
Belongs to the nectin family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.