CCRL1 Antibody - #DF3541
| 製品: | CCRL1 Antibody |
| カタログ: | DF3541 |
| タンパク質の説明: | Rabbit polyclonal antibody to CCRL1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 40 KD; 40kD(Calculated). |
| ユニプロット: | Q9NPB9 |
| RRID: | AB_2835914 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3541, RRID:AB_2835914.
折りたたみ／展開
ACKR4; Atypical chemokine receptor 4; C C chemokine receptor type 11; C-C chemokine receptor type 11; C-C CKR-11; CC chemokine receptor like 1; CC chemokine receptor-like 1; CC CKR 11; CC-CKR-11; CCBP2; CCCKR11; CCR 11; CCR-11; CCR10; CCRL1; CCRL1_HUMAN; CCX CKR; Chemocentryx chemokine receptor; Chemokine (C C motif) receptor like 1; Chemokine cc motif receptor like protein 1; Chemokine receptor like 1; CKR11; CKRB; Orphan seven transmembrane receptor chemokine related; PPR1; VSHK1;
免疫原
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
- Q9NPB9 ACKR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NPB9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S146 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T244 | Phosphorylation | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| Y256 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| Y321 | Phosphorylation | Uniprot |
研究背景
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
Early endosome. Recycling endosome. Cell membrane>Multi-pass membrane protein.
Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
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