CDCA2 Antibody - #DF3543
(1)
(11)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3543, RRID:AB_2835916.
折りたたみ／展開
cell division cycle associated 2; PPP1R81; protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man; protein phosphatase 1, regulatory subunit 81; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo Man; Repo-Man;
免疫原
- Q69YH5 CDCA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q69YH5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Methylation | Uniprot | |
| K13 | Methylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| K52 | Methylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| R96 | Methylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| R106 | Methylation | Uniprot | |
| K115 | Acetylation | Uniprot | |
| K119 | Acetylation | Uniprot | |
| K119 | Methylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| Y135 | Phosphorylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot | |
| K323 | Ubiquitination | Uniprot | |
| T324 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| T412 | Phosphorylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| K494 | Ubiquitination | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| S591 | Phosphorylation | Uniprot | |
| T603 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot | |
| K622 | Acetylation | Uniprot | |
| K622 | Sumoylation | Uniprot | |
| K627 | Acetylation | Uniprot | |
| T628 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| C714 | S-Nitrosylation | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| S724 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| S756 | Phosphorylation | Uniprot | |
| K762 | Sumoylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K776 | Ubiquitination | Uniprot | |
| R813 | Methylation | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| S874 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| S893 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| S930 | Phosphorylation | Uniprot | |
| S936 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| S960 | Phosphorylation | Uniprot | |
| S977 | Phosphorylation | Uniprot | |
| S1000 | Phosphorylation | Uniprot |
研究背景
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Phosphorylated by CDK1. May regulate its subcellular location.
Nucleus.
Note: Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Ubiquitously expressed.
Interacts with PPP1CC.
参考文献
Application: WB Species: Human Sample: liver tissues
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