Cytochrome P450 39A1 Antibody - #DF3585
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3585, RRID:AB_2835957.
折りたたみ／展開
24 hydroxycholesterol 7 alpha hydroxylase; 24-hydroxycholesterol 7-alpha-hydroxylase; CP39A_HUMAN; Cyp39a1; cytochrome P450 family 39, subfamily A polypeptide 1; Cytochrome P450 39A1; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1; Cytochrome P450, family 39, subfamily a, polypeptide 1; hCYP39A1; Oxysterol 7 alpha hydroxylase; Oxysterol 7-alpha-hydroxylase; oxysterol 7alpha hydroxylase;
免疫原
- Q9NYL5 CP39A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NYL5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y102 | Phosphorylation | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| T345 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot |
研究背景
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Endoplasmic reticulum membrane>Multi-pass membrane protein. Microsome membrane>Multi-pass membrane protein.
Liver specific.
Belongs to the cytochrome P450 family.
研究領域
· Metabolism > Lipid metabolism > Primary bile acid biosynthesis.
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