Cytochrome P450 51A1 Antibody - #DF3591
| 製品: | Cytochrome P450 51A1 Antibody |
| カタログ: | DF3591 |
| タンパク質の説明: | Rabbit polyclonal antibody to Cytochrome P450 51A1 |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Pig, Dog |
| 分子量: | 57 KD; 57kD(Calculated). |
| ユニプロット: | Q16850 |
| RRID: | AB_2835963 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3591, RRID:AB_2835963.
折りたたみ／展開
CP51; CP51A_HUMAN; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrome P450 51; Cytochrome P450 51A1; Cytochrome P450 family 51 subfamily A member 1; Cytochrome P450 family 51 subfamily A polypeptide 1; Cytochrome P450, 51 (lanosterol 14 alpha demethylase); Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; LDM; P450 14DM; P450L1; Sterol 14-alpha demethylase;
免疫原
Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
- Q16850 CP51A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16850 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S12 | Phosphorylation | Uniprot | |
| K59 | Sumoylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| K79 | Sumoylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| R365 | Methylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| T370 | Phosphorylation | Uniprot | |
| Y393 | Phosphorylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| Y456 | Phosphorylation | Uniprot |
研究背景
A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Endoplasmic reticulum membrane>Single-pass membrane protein. Microsome membrane>Single-pass membrane protein.
Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
Belongs to the cytochrome P450 family.
研究領域
· Metabolism > Lipid metabolism > Steroid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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