PSMD11 Antibody - #DF3643
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3643, RRID:AB_2836015.
折りたたみ／展開
26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; MGC3844; p44.5; protease 26S, subunit, 9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; proteasome 26S subunit, non-ATPase, 11; PSD11_HUMAN; PSMD 11; PSMD11; Rpn6; S9;
免疫原
Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
- O00231 PSD11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00231 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| R11 | Methylation | Uniprot | |
| S14 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| R20 | Methylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K141 | Acetylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| Y201 | Phosphorylation | Uniprot | |
| C202 | S-Nitrosylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| T209 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| C289 | S-Nitrosylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| K304 | Methylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| Y397 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| Y415 | Phosphorylation | Uniprot | |
| K417 | Acetylation | Uniprot | |
| K417 | Ubiquitination | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Phosphorylated by AMPK.
Nucleus. Cytoplasm>Cytosol.
Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD11, a base containing 6 ATPases and few additional components.
Belongs to the proteasome subunit S9 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.