PSMD12 Antibody - #DF3644
| 製品: | PSMD12 Antibody |
| カタログ: | DF3644 |
| タンパク質の説明: | Rabbit polyclonal antibody to PSMD12 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 50 KD; 53kD(Calculated). |
| ユニプロット: | O00232 |
| RRID: | AB_2836016 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3644, RRID:AB_2836016.
折りたたみ／展開
26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; p55; proteasome (prosome, macropain) 26S subunit, non ATPase12; Proteasome 26S non ATPase subunit 12 isoform 2; PSD12_HUMAN; PSMD12; Rpn5;
免疫原
- O00232 PSD12_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00232 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K92 | Sumoylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| C255 | S-Nitrosylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K368 | Acetylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| K448 | Acetylation | Uniprot | |
| K448 | Ubiquitination | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD12, a base containing 6 ATPases and few additional components. Interacts with ERCC6.
Belongs to the proteasome subunit p55 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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