MRPL41 Antibody - #DF3670
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3670, RRID:AB_2836042.
折りたたみ／展開
39S ribosomal protein L27 homolog; 39S ribosomal protein L41; 39S ribosomal protein L41 mitochondrial; Bcl-2-interacting mitochondrial ribosomal protein L41; BMRP; Cell proliferation-inducing gene 3 protein; L41mt; mitochondrial; Mitochondrial ribosomal protein L41; MRP L27; MRP-L27 homolog; MRP-L41; MRPL27; mRpL41; PIG3; Proliferation inducing gene 3; RM41_HUMAN; RPML27;
免疫原
A synthesized peptide derived from human MRPL41, corresponding to a region within C-terminal amino acids.
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
- Q8IXM3 RM41_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGVLAAAARCLVRGADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPDLTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDNLEKYGFEPTQEGKLFQLYPRNFLR
PTMs - Q8IXM3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K105 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot |
研究背景
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Mitochondrion.
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. Interacts with BCL2.
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
参考文献
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