MAN1B1 Antibody - #AF0386
| 製品: | MAN1B1 Antibody |
| カタログ: | AF0386 |
| タンパク質の説明: | Rabbit polyclonal antibody to MAN1B1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 80kDa; 80kD(Calculated). |
| ユニプロット: | Q9UKM7 |
| RRID: | AB_2833542 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0386, RRID:AB_2833542.
折りたたみ／展開
Alpha 1 2 mannosidase; Endoplasmic reticulum alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase; ER alpha 1 2 mannosidase; Man9GlcNAc2 specific processing alpha mannosidase; MANA ER; Mannosidase alpha class 1B member 1;
免疫原
- Q9UKM7 MA1B1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
PTMs - Q9UKM7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T21 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S174 | O-Glycosylation | Uniprot | |
| T204 | O-Glycosylation | Uniprot | |
| T219 | O-Glycosylation | Uniprot | |
| S223 | O-Glycosylation | Uniprot | |
| T230 | O-Glycosylation | Uniprot | |
| T239 | O-Glycosylation | Uniprot | |
| T242 | O-Glycosylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| K354 | Acetylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T381 | O-Glycosylation | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| Y487 | Phosphorylation | Uniprot | |
| T508 | O-Glycosylation | Uniprot | |
| T565 | Phosphorylation | Uniprot | |
| Y577 | Phosphorylation | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K649 | Ubiquitination | Uniprot |
研究背景
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).
Endoplasmic reticulum membrane>Single-pass type II membrane protein.
Widely expressed.
Belongs to the glycosyl hydrolase 47 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Metabolism > Glycan biosynthesis and metabolism > N-Glycan biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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