TROVE2 Antibody - #DF3693
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3693, RRID:AB_2836057.
折りたたみ／展開
60 kDa ribonucleoprotein Ro; 60 kDa Ro protein; 60 kDa SS A/Ro ribonucleoprotein; 60 kDa SS-A/Ro ribonucleoprotein; Autoantigen Ro/SSA, 60-KD; bA101E13.2; Gastric cancer multi drug resistance protein; Ribonucleoprotein autoantigen SS A/Ro; RO 60; Ro 60 kDa autoantigen; RO60; RO60_HUMAN; RoRNP; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A2 (60kD ribonucleoprotein autoantigen SS A/Ro); Sjogren syndrome antigen A2 (60kDa ribonucleoprotein autoantigen SS A/Ro); Sjogren syndrome antigen A2; SS A; SS-A; SS-A/Ro; SSA 2; SSA; SSA2; TROVE 2; TROVE domain family member 2; TROVE2;
免疫原
A synthesized peptide derived from human TROVE2, corresponding to a region within N-terminal amino acids.
- P10155 RO60_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLPMIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDMI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10155 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| R69 | Methylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| K113 | Methylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K170 | Acetylation | Uniprot | |
| K170 | Methylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| Y201 | Phosphorylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| K224 | Acetylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K312 | Acetylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K359 | Acetylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot |
研究背景
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.
May play roles in cilia formation and/or maintenance.
Cytoplasm.
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
Belongs to the Ro 60 kDa family.
研究領域
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
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