ACOT2 Antibody - #DF3734
| 製品: | ACOT2 Antibody |
| カタログ: | DF3734 |
| タンパク質の説明: | Rabbit polyclonal antibody to ACOT2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Bovine |
| 分子量: | 53 KD; 53kD(Calculated). |
| ユニプロット: | P49753 |
| RRID: | AB_2836098 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3734, RRID:AB_2836098.
折りたたみ／展開
AA571646; ACOT2; Acyl CoA thioesterase 2; Acyl coenzyme A thioester hydrolase 2a; Acyl coenzyme A thioesterase 2, mitochondrial; CTE Ia; CTE1A; Long chain acyl CoA thioesterase 2; Mitochondrial acyl CoA thioesterase 1; Mitochondrial acyl CoA thioesterase 2; MTE1; Peroxisomal long chain acyl coA; PTE2; PTE2A; ZAP128;
免疫原
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
- P49753 ACOT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49753 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| R86 | Methylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| K402 | Acetylation | Uniprot | |
| K462 | Acetylation | Uniprot | |
| K482 | Ubiquitination | Uniprot |
研究背景
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).
Mitochondrion.
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
Monomer.
Belongs to the C/M/P thioester hydrolase family.
研究領域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Ovarian steroidogenesis.
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