SLC25A6 Antibody - #DF3742
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3742, RRID:AB_2836106.
折りたたみ／展開
AAC3; Adenine nucleotide translocator 3; ADP; ADP ATP carrier protein 3; ADP ATP carrier protein isoform T2; ADP ATP carrier protein liver; ADP/ATP translocase 3; ADP/ATP translocator of liver; ADT3_HUMAN; ANT 2; ANT 3; ANT; ANT3; ANT3Y; ATP carrier protein 3; ATP carrier protein; CDABP0051; isoform T2; MGC17525; SLC25A6; Solute carrier family 25 (mitochondrial carrier adenine nucleotide translocator) member 6; Solute carrier family 25 member 6;
免疫原
- P12236 ADT3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P12236 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T2 | Acetylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Methylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K23 | Acetylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K49 | Methylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| Y51 | Phosphorylation | Uniprot | |
| K52 | Methylation | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| T84 | Phosphorylation | Uniprot | |
| K92 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| T139 | Phosphorylation | Uniprot | |
| R140 | Methylation | Uniprot | |
| K147 | Acetylation | Uniprot | |
| K147 | Methylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| R155 | Methylation | Uniprot | |
| C160 | S-Nitrosylation | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K199 | Sumoylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K206 | Sumoylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K268 | Acetylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K272 | Acetylation | Uniprot | |
| K272 | Methylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| S276 | Phosphorylation | Uniprot |
研究背景
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Trimethylated by ANTKMT at Lys-52.
Mitochondrion inner membrane>Multi-pass membrane protein.
Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.
Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer.
(Microbial infection) Interacts with influenza A virus PB1-F2 protein.
(Microbial infection) Interacts with HIV-1 Vpr.
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Belongs to the mitochondrial carrier (TC 2.A.29) family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
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