BST1 Antibody - #DF3744

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製品: BST1 Antibody
カタログ: DF3744
タンパク質の説明: Rabbit polyclonal antibody to BST1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Rabbit, Dog, Chicken
分子量: 34 KD; 36kD(Calculated).
ユニプロット: Q10588
RRID: AB_2836108

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MS Report
HPLC Report
MSDS
説明書
COA
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Rabbit(80%), Dog(90%), Chicken(80%)
クローナリティ:
Polyclonal
特異性:
BST1 Antibody detects endogenous levels of total BST1.
RRID:
AB_2836108
引用形式: Affinity Biosciences Cat# DF3744, RRID:AB_2836108.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ADP ribosyl cyclase 2; ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BST 1; BST-1; BST1; BST1_HUMAN; cADPr hydrolase 2; CD157; CD157 antigen; Cyclic ADP ribose hydrolase 2; Cyclic ADP-ribose hydrolase 2; NAD(+) nucleosidase; OTTHUMP00000217617;

免疫原

免疫原:
Uniprot:

Q10588(BST1_HUMAN) >>Visit HPA database.

遺伝子(ID):
BST1(683)
発現特異性:
Q10588 BST1_HUMAN:

Widely expressed.

タンパク質配列:
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQRAGLIIPLFLVLASRTQL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Dog
90
Chicken
80
Rabbit
80
Xenopus
70
Horse
0
Sheep
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q10588 基板として

Site PTM Type Enzyme
N95 N-Glycosylation
N192 N-Glycosylation
Y263 Phosphorylation

研究背景

機能:

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

細胞の位置付け:

Cell membrane>Lipid-anchor.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed.

サブユニット構造:

Homodimer.

タンパク質ファミリー:

Belongs to the ADP-ribosyl cyclase family.

研究領域

· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

参考文献

1). Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast. Redox Biology, 2022 (PubMed: 35926314) [IF=11.4]

Application: WB    Species: Mouse    Sample:

Fig. 5. NAD + depletion in pregnant mice triggered by DEHP. Pregnant mice were administrated by DEHP (0, 5, 50 and 200 mg/kg/d) during GD 0–15. HTR-8 cells were treated with MEHP (0, 20, 200, 500 μM) for 24 h. NAD+ content was measured in (A–D) serum, (E–H) placenta, and (I–L) HTR-8 cells, respectively. (M) CD38, CD157, and (N) NAMPT representative images of Western blot. Quantifications of (O) CD38, (P) CD157, and (Q) NAMPT expression in mice placenta based on band intensity were shown below the blots. All data are expressed as mean ± standard errors. (N = 6). * indicate a statistically significant difference compared to control (P < 0.05).

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