APOA5 Antibody - #DF3783
| 製品: | APOA5 Antibody |
| カタログ: | DF3783 |
| タンパク質の説明: | Rabbit polyclonal antibody to APOA5 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep |
| 分子量: | 41 KD; 41kD(Calculated). |
| ユニプロット: | Q6Q788 |
| RRID: | AB_2836140 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3783, RRID:AB_2836140.
折りたたみ／展開
Apo-AV; ApoA-V; Apoa5; APOA5_HUMAN; ApoAV; Apolipoprotein A-V; Apolipoprotein A5; RAP3; Regeneration associated protein 3; Regeneration-associated protein 3;
免疫原
- Q6Q788 APOA5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6Q788 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T55 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S80 | O-Glycosylation | Uniprot |
研究背景
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
Phosphorylated by FAM20C in the extracellular medium.
Secreted. Early endosome. Late endosome. Golgi apparatus>trans-Golgi network.
Note: In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network.
Liver and plasma.
Interacts with GPIHBP1. Interacts with SORL1; this interaction leads to APOA5 internalization and sorting either to lysosomes and degradation, or to the trans-Golgi network.
Belongs to the apolipoprotein A1/A4/E family.
研究領域
· Organismal Systems > Endocrine system > PPAR signaling pathway.
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