ARG1 Antibody - #DF3791
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| 製品: | ARG1 Antibody |
| カタログ: | DF3791 |
| タンパク質の説明: | Rabbit polyclonal antibody to ARG1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 35 KD; 35kD(Calculated). |
| ユニプロット: | P05089 |
| RRID: | AB_2836148 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3791, RRID:AB_2836148.
折りたたみ／展開
A I; Al; ARG 1; arg1; ARGI1_HUMAN; Arginase 1; Arginase liver; Arginase type I; Arginase, liver; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase;
免疫原
Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409).
- P05089 ARGI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P05089 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| C168 | S-Nitrosylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| K191 | Acetylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| C303 | S-Nitrosylation | Uniprot |
研究背景
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.
Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Cytoplasm. Cytoplasmic granule.
Note: Localized in azurophil granules of neutrophils (PubMed:15546957).
Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Homotrimer. Interacts with CMTM6.
Belongs to the arginase family.
研究領域
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Metabolism > Amino acid metabolism > Arginine biosynthesis.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
参考文献
Application: WB Species: Mouse Sample: hippocampus
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