SLC27A5 Antibody - #DF3845
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3845, RRID:AB_2836202.
折りたたみ／展開
ACSB; ACSVL6; BA CoA ligase; BA-CoA ligase; BACS; BAL; Bile acid CoA ligase; Bile acid-CoA ligase; Bile acyl CoA synthetase; Bile acyl-CoA synthetase; Cholate CoA ligase; Cholate--CoA ligase; FACVL3; FATP 5; FATP-5; FATP5; Fatty acid Coenzyme A ligase very long chain 3; Fatty acid transport protein 5; Fatty-acid-coenzyme A ligase; FLJ22987; S27A5_HUMAN; Slc27a5; Solute carrier family 27 (fatty acid transporter) member 5; Solute carrier family 27 member 5; Very long chain acyl CoA synthetase homolog 2; Very long chain acyl CoA synthetase related protein; very long-chain 3; Very long-chain acyl-CoA synthetase homolog 2; Very long-chain acyl-CoA synthetase-related protein; VLACS related; VLACS-related; VLACSR; VLCS H2; VLCS-H2; VLCSH2;
免疫原
- Q9Y2P5 S27A5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGVRQQLALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILHLGLKIRGCLSRQPPDTFVDAFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAELGDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLSHTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y2P5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K241 | Acetylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| Y613 | Phosphorylation | Uniprot |
研究背景
Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates. Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity. Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein. Microsome. Cell membrane>Multi-pass membrane protein.
Predominantly expressed in liver.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Lipid metabolism > Primary bile acid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
参考文献
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