BCAS2 Antibody - #DF3855
| 製品: | BCAS2 Antibody |
| カタログ: | DF3855 |
| タンパク質の説明: | Rabbit polyclonal antibody to BCAS2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 27 KD; 26kD(Calculated). |
| ユニプロット: | O75934 |
| RRID: | AB_2836212 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3855, RRID:AB_2836212.
折りたたみ／展開
bcas2; Breast carcinoma amplified sequence 2; Breast carcinoma-amplified sequence 2; DAM1; DNA amplified in mammary carcinoma 1 protein; MGC7712; Pre mRNA splicing factor SPF27; Pre-mRNA-splicing factor spf27; Snt309; SPF27; SPF27_HUMAN; Spliceosome associated protein amplified in breast cancer; Spliceosome associated protein SPF 27; Spliceosome-associated protein SPF 27;
免疫原
- O75934 SPF27_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75934 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| Y87 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K218 | Ubiquitination | Uniprot |
研究背景
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Nucleus. Nucleus>Nucleolus.
Ubiquitously expressed.
Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1.
Belongs to the SPF27 family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
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