ABCC3 Antibody - #DF3874
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3874, RRID:AB_2836227.
折りたたみ／展開
ABC 31; ABC31; ABCC 3; ABCC3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C member 3; ATP-binding cassette sub-family C member 3; Canalicular multispecific organic anion transporter 2; Canicular multispecific organic anion transporter; CMOAT 2; CMOAT2; EST90757; MLP 2; MLP2; MOAT D; MOAT-D; MOATD; MRP 3; MRP3_HUMAN; Multi specific organic anion transporter D; Multi-specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multidrug resistance-associated protein 3; Multispecific organic anion tranporter D;
免疫原
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
- O15438 MRP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15438 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K160 | Ubiquitination | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| Y231 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K265 | Methylation | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| Y720 | Phosphorylation | Uniprot | |
| S767 | Phosphorylation | Uniprot | |
| K803 | Ubiquitination | Uniprot | |
| T882 | Phosphorylation | Uniprot | |
| S884 | Phosphorylation | Uniprot | |
| T887 | Phosphorylation | Uniprot | |
| T896 | Phosphorylation | Uniprot | |
| S908 | Phosphorylation | Uniprot | |
| S911 | Phosphorylation | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| K931 | Ubiquitination | Uniprot | |
| K938 | Ubiquitination | Uniprot | |
| K1052 | Ubiquitination | Uniprot | |
| S1141 | Phosphorylation | Uniprot | |
| K1177 | Ubiquitination | Uniprot | |
| S1248 | Phosphorylation | Uniprot | |
| K1344 | Ubiquitination | Uniprot | |
| K1498 | Ubiquitination | Uniprot |
研究背景
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Membrane>Multi-pass membrane protein.
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
研究領域
· Environmental Information Processing > Membrane transport > ABC transporters.
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
参考文献
Application: WB Species: human Sample: MDA-MB-231 and MDA-MB-231/ADR cells
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