CBR1 Antibody - #DF3893
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3893, RRID:AB_2836246.
折りたたみ／展開
15 hydroxyprostaglandin dehydrogenase [NADP+]; 15-hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; Carbonyl Reductase 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase; Prostaglandin E(2) 9 reductase; Prostaglandin-E(2) 9-reductase; SDR21C1;
免疫原
- P16152 CBR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P16152 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| T36 | Phosphorylation | Uniprot | |
| R42 | Methylation | Uniprot | |
| S56 | Phosphorylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K181 | Acetylation | Uniprot | |
| K186 | Acetylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| K198 | Acetylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| K272 | Ubiquitination | Uniprot |
研究背景
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Cytoplasm.
Monomer.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
研究領域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
参考文献
Application: WB Species: human Sample: maternal placenta, liver, and pancreas
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