製品: CPB2 Antibody
カタログ: DF3897
タンパク質の説明: Rabbit polyclonal antibody to CPB2
アプリケーション: WB IF/ICC
反応性: Human
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 48 KD; 48kD(Calculated).
ユニプロット: Q96IY4
RRID: AB_2836250

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Pig(91%), Zebrafish(82%), Bovine(90%), Horse(90%), Sheep(90%), Rabbit(100%), Dog(91%), Chicken(91%), Xenopus(90%)
クローナリティ:
Polyclonal
特異性:
CPB2 Antibody detects endogenous levels of total CPB2.
RRID:
AB_2836250
引用形式: Affinity Biosciences Cat# DF3897, RRID:AB_2836250.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

1110032P04Rik; 4930405E17Rik; bA139H14.2; Carboxypeptidase B like protein; Carboxypeptidase U; CarboxypeptidaseB2; CarboxypeptidaseU; CP B2; CPB 2; CPB2; CPU; PCPB; Plasma carboxypeptidase B; Plasma carboxypeptidase B2; Procarboxypeptidase B; Procarboxypeptidase R; Procarboxypeptidase U; TAFI; Thrombin activable fibrinolysis inhibitor; Thrombin activatable fibrinolysis inhibitor;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q96IY4 CBPB2_HUMAN:

Plasma; synthesized in the liver.

タンパク質配列:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
91
Dog
91
Chicken
91
Horse
90
Bovine
90
Sheep
90
Xenopus
90
Zebrafish
82
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96IY4 基板として

Site PTM Type Enzyme
N44 N-Glycosylation
N73 N-Glycosylation
N85 N-Glycosylation
N108 N-Glycosylation
N241 N-Glycosylation
S338 Phosphorylation
Y380 Phosphorylation
T383 Phosphorylation

研究背景

機能:

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

PTMs:

N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Plasma; synthesized in the liver.

タンパク質ファミリー:

Belongs to the peptidase M14 family.

研究領域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

· Organismal Systems > Digestive system > Pancreatic secretion.

· Organismal Systems > Digestive system > Protein digestion and absorption.

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