CPE Antibody - #DF3898
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3898, RRID:AB_2836251.
折りたたみ／展開
Carboxypeptidase E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE_HUMAN; Cobalt stimulated chromaffin granule carboxypeptidase; CPE; Cph 1; CPH; Enkephalin convertase; Entephalin convertase; Insulin granule associated carboxypeptidase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase;
免疫原
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
- P16870 CBPE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P16870 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K164 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| T403 | Phosphorylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| Y428 | Phosphorylation | Uniprot | |
| T432 | Phosphorylation | Uniprot | |
| K433 | Methylation | Uniprot | |
| K433 | Ubiquitination | Uniprot |
研究背景
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
Cytoplasmic vesicle>Secretory vesicle. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Secreted.
Note: Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Nucleus.
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
Interacts with secretogranin III/SCG3 (By similarity). Isoform 2 interacts with HDAC1 and HDAC2.
Belongs to the peptidase M14 family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Type I diabetes mellitus.
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