NCAPG Antibody - #DF3968
| 製品: | NCAPG Antibody |
| カタログ: | DF3968 |
| タンパク質の説明: | Rabbit polyclonal antibody to NCAPG |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 114 KD; 114kD(Calculated). |
| ユニプロット: | Q9BPX3 |
| RRID: | AB_2836321 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3968, RRID:AB_2836321.
折りたたみ／展開
CAPG; CHCG; Chromosome associated protein G; Chromosome condensation protein G; Condensin complex subunit 3; Condensin subunit CAP G; HCAP G; Melanoma antigen NY MEL 3; NCAPG; Non SMC condensin I complex subunit G; NY MEL 3; XCAP G homolog;
免疫原
- Q9BPX3 CND3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAERRLLSIKEAFRLAQQPHQNQAKLVVALSRTYRTMDDKTVFHEEFIHYLKYVMVVYKREPAVERVIEFAAKFVTSFHQSDMEDDEEEEDGGLLNYLFTFLLKSHEANSNAVRFRVCLLINKLLGSMPENAQIDDDVFDKINKAMLIRLKDKIPNVRIQAVLALSRLQDPKDDECPVVNAYATLIENDSNPEVRRAVLSCIAPSAKTLPKIVGRTKDVKEAVRKLAYQVLAEKVHMRAMSIAQRVMLLQQGLNDRSDAVKQAMQKHLLQGWLRFSEGNILELLHRLDVENSSEVAVSVLNALFSITPLSELVGLCKNNDGRKLIPVETLTPEIALYWCALCEYLKSKGDEGEEFLEQILPEPVVYADYLLSYIQSIPVVNEEHRGDFSYIGNLMTKEFIGQQLILIIKSLDTSEEGGRKKLLAVLQEILILPTIPISLVSFLVERLLHIIIDDNKRTQIVTEIISEIRAPIVTVGVNNDPADVRKKELKMAEIKVKLIEAKEALENCITLQDFNRASELKEEIKALEDARINLLKETEQLEIKEVHIEKNDAETLQKCLILCYELLKQMSISTGLSATMNGIIESLILPGIISIHPVVRNLAVLCLGCCGLQNQDFARKHFVLLLQVLQIDDVTIKISALKAIFDQLMTFGIEPFKTKKIKTLHCEGTEINSDDEQESKEVEETATAKNVLKLLSDFLDSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLILLWYNPVTEEDVQLRHCLGVFFPVFAYASRTNQECFEEAFLPTLQTLANAPASSPLAEIDITNVAELLVDLTRPSGLNPQAKTSQDYQALTVHDNLAMKICNEILTSPCSPEIRVYTKALSSLELSSHLAKDLLVLLNEILEQVKDRTCLRALEKIKIQLEKGNKEFGDQAEAAQDATLTTTTFQNEDEKNKEVYMTPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRLPRRAKTAALEKSKLNLAQFLNEDLS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BPX3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| K11 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| R257 | Methylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| T308 | Phosphorylation | P06493 (CDK1) | Uniprot |
| T332 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S390 | Phosphorylation | Uniprot | |
| T397 | Phosphorylation | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| K491 | Acetylation | Uniprot | |
| K496 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| T664 | Phosphorylation | Uniprot | |
| T670 | Phosphorylation | Uniprot | |
| S674 | Phosphorylation | Uniprot | |
| S680 | Phosphorylation | Uniprot | |
| T686 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| S697 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| K717 | Ubiquitination | Uniprot | |
| T817 | Phosphorylation | Uniprot | |
| S818 | Phosphorylation | Uniprot | |
| Y821 | Phosphorylation | Uniprot | |
| K833 | Ubiquitination | Uniprot | |
| S841 | Phosphorylation | Uniprot | |
| S844 | Phosphorylation | Uniprot | |
| T851 | Phosphorylation | Uniprot | |
| K852 | Ubiquitination | Uniprot | |
| K891 | Ubiquitination | Uniprot | |
| K896 | Ubiquitination | Uniprot | |
| K899 | Ubiquitination | Uniprot | |
| Y929 | Phosphorylation | Uniprot | |
| T931 | Phosphorylation | P06493 (CDK1) | Uniprot |
| R934 | Methylation | Uniprot | |
| K937 | Ubiquitination | Uniprot | |
| K943 | Ubiquitination | Uniprot | |
| S944 | Phosphorylation | Uniprot | |
| T945 | Phosphorylation | Uniprot | |
| S959 | Phosphorylation | Uniprot | |
| T968 | Phosphorylation | Uniprot | |
| S973 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S975 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S984 | Phosphorylation | Uniprot | |
| T996 | Phosphorylation | Uniprot | |
| S1002 | Phosphorylation | Uniprot | |
| K1003 | Ubiquitination | Uniprot | |
| S1015 | Phosphorylation | Uniprot |
研究背景
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
Nucleus. Cytoplasm. Chromosome.
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Highly expressed in testis.
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
Belongs to the CND3 (condensin subunit 3) family.
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