製品: CCS/SOD4 Antibody
カタログ: DF3971
タンパク質の説明: Rabbit polyclonal antibody to CCS/SOD4
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Horse, Sheep, Rabbit
分子量: 32 KD; 29kD(Calculated).
ユニプロット: O14618
RRID: AB_2836324

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(80%), Horse(90%), Sheep(80%), Rabbit(90%)
クローナリティ:
Polyclonal
特異性:
CCS/SOD4 Antibody detects endogenous levels of total CCS/SOD4.
RRID:
AB_2836324
引用形式: Affinity Biosciences Cat# DF3971, RRID:AB_2836324.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

CCS; CCS_HUMAN; Copper chaperone for superoxide dismutase; MGC138260; SOD 4; SOD4; Superoxide dismutase copper chaperone; Superoxide Dismutase 4;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O14618 CCS_HUMAN:

Ubiquitous.

タンパク質配列:
MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
90
Horse
90
Pig
80
Sheep
80
Dog
70
Bovine
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O14618 基板として

Site PTM Type Enzyme
K76 Ubiquitination
R165 Methylation
K189 Ubiquitination
R209 Methylation
K216 Ubiquitination
K241 Ubiquitination
S267 Phosphorylation

研究背景

機能:

Delivers copper to copper zinc superoxide dismutase (SOD1).

PTMs:

Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous.

サブユニット構造:

Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4.

タンパク質ファミリー:

In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

研究領域

· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).

参考文献

1). Metformin-based carbon dots based on biguanide functional groups for simultaneous chelation of copper ions and inhibitable colorectal cancer therapy. Carbon, 2023 [IF=10.9]

2). Inhibition of ASIC1a-Mediated ERS Improves the Activation of HSCs and Copper Transport Under Copper Load. Frontiers in Pharmacology, 2021 (PubMed: 34135753) [IF=5.6]

3). Associations of polymorphisms in LOXL1 and copper chaperone genes with pseudoexfoliation-syndrome-related cataract in a Chinese Uygur population. INTERNATIONAL OPHTHALMOLOGY, 2020 (PubMed: 32253563) [IF=1.6]

Application: WB    Species: human    Sample: lens capsule

Fig. 1 |CCS expression levels. a Western blotting of the CCS protein in the lens capsule. CCS expression was greater in the PEXC group than in the ARC group

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For Research Use Only.
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