CCS/SOD4 Antibody - #DF3971
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3971, RRID:AB_2836324.
折りたたみ/展開
CCS; CCS_HUMAN; Copper chaperone for superoxide dismutase; MGC138260; SOD 4; SOD4; Superoxide dismutase copper chaperone; Superoxide Dismutase 4;
免疫原
- O14618 CCS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14618 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K76 | Ubiquitination | Uniprot | |
R165 | Methylation | Uniprot | |
K189 | Ubiquitination | Uniprot | |
R209 | Methylation | Uniprot | |
K216 | Ubiquitination | Uniprot | |
K241 | Ubiquitination | Uniprot | |
S267 | Phosphorylation | Uniprot |
研究背景
Delivers copper to copper zinc superoxide dismutase (SOD1).
Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
Cytoplasm.
Ubiquitous.
Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4.
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
研究領域
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
参考文献
Application: WB Species: human Sample: lens capsule
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