POLR1C Antibody - #DF4008
| 製品: | POLR1C Antibody |
| カタログ: | DF4008 |
| タンパク質の説明: | Rabbit polyclonal antibody to POLR1C |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 39 KD; 39kD(Calculated). |
| ユニプロット: | O15160 |
| RRID: | AB_2836368 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4008, RRID:AB_2836368.
折りたたみ／展開
40kDa; AA409007; AA959927; Ac2-127; AC40; AL024089; DNA directed RNA polymerase I subunit C; DNA directed RNA polymerases I and III 40 kDa polypeptide; DNA directed RNA polymerases I and III subunit RPAC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; MGC105583; MGC161175; POLR1C; POLR1E; Polymerase (RNA) I polypeptide C, 30kDa; RNA polymerase 1 1; RNA polymerases I and III subunit AC1; RP3-337H4.4; RPA39; RPA40; RPA5; RPAC1; RPAC1_HUMAN; RPC40; Rpo1 1; TCS3;
免疫原
- O15160 RPAC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15160 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| Y33 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| Y36 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| R120 | Methylation | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| R125 | Methylation | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| C256 | S-Nitrosylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot |
研究背景
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Nucleus.
Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
研究領域
· Genetic Information Processing > Transcription > RNA polymerase.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway. (View pathway)
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