GNAL Antibody - #DF4108
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4108, RRID:AB_2836399.
折りたたみ／展開
;Adenylate cyclase stimulating G alpha protein, olfactory type; Adenylate cyclase-stimulating G alpha protein; DYT25; G alpha olf; Gnal; GNAL_HUMAN; Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type; Guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type; Guanine nucleotide binding protein G(olf) subunit alpha; Guanine nucleotide-binding protein G(olf) subunit alpha; olfactory type;
免疫原
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
- P38405 GNAL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGCLGGNSKTTEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P38405 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K30 | Ubiquitination | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| Y347 | Phosphorylation | Uniprot |
研究背景
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GAS2L2.
Belongs to the G-alpha family. G(s) subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Sensory system > Olfactory transduction.
参考文献
Application: WB Species: Rat Sample:
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