GNL3L Antibody - #DF4113
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| 製品: | GNL3L Antibody |
| カタログ: | DF4113 |
| タンパク質の説明: | Rabbit polyclonal antibody to GNL3L |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Monkey |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 66 KD; 66kD(Calculated). |
| ユニプロット: | Q9NVN8 |
| RRID: | AB_2836404 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4113, RRID:AB_2836404.
折りたたみ／展開
FLJ10613; Guanine nucleotide binding protein-like 3 (nucleolar)-like; novel GTPase; OTTHUMP00000023374;
免疫原
- Q9NVN8 GNL3L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NVN8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K20 | Sumoylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K62 | Sumoylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K200 | Methylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| K375 | Sumoylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| K469 | Ubiquitination | Uniprot | |
| K477 | Sumoylation | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| K482 | Sumoylation | Uniprot | |
| K482 | Ubiquitination | Uniprot | |
| Y489 | Phosphorylation | Uniprot | |
| K502 | Acetylation | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| S513 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | Uniprot |
研究背景
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Nucleus>Nucleolus.
Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Belongs to the TRAFAC class YlqF/YawG GTPase family.
研究領域
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
参考文献
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