Phospho-HBP1 (Ser402) Antibody - #AF0031
| 製品: | Phospho-HBP1 (Ser402) Antibody |
| カタログ: | AF0031 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-HBP1 (Ser402) |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 58kDa; 58kD(Calculated). |
| ユニプロット: | O60381 |
| RRID: | AB_2833291 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0031, RRID:AB_2833291.
折りたたみ／展開
FLJ16340; HBP 1; HBP1; HBP1_HUMAN; High mobility group box transcription factor 1; HMG box containing protein 1; HMG box transcription factor 1; HMG box-containing protein 1;
免疫原
- O60381 HBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60381 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K16 | Ubiquitination | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K171 | Acetylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| K297 | Acetylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K305 | Acetylation | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K307 | Acetylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| S402 | Phosphorylation | Q15759 (MAPK11) , Q16539 (MAPK14) | Uniprot |
| K416 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| T484 | Phosphorylation | Uniprot | |
| K488 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| S509 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation.
Nucleus.
Binds the second PAH repeat of SIN3A (Probable). Binds TCF4. Binds RB1.
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