GGH Antibody - #DF4073
| 製品: | GGH Antibody |
| カタログ: | DF4073 |
| タンパク質の説明: | Rabbit polyclonal antibody to GGH |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 36 KD; 36kD(Calculated). |
| ユニプロット: | Q92820 |
| RRID: | AB_2836447 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4073, RRID:AB_2836447.
折りたたみ／展開
Conjugase; folylpolygammaglutamyl hydrolase; gamma glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Gamma-glutamyl hydrolase; GGH; GGH_HUMAN; gH;
免疫原
- Q92820 GGH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92820 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K81 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| N163 | N-Glycosylation | Uniprot | |
| N203 | N-Glycosylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| N307 | N-Glycosylation | Uniprot |
研究背景
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Secreted>Extracellular space. Lysosome. Melanosome.
Note: While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Homodimer.
Belongs to the peptidase C26 family.
研究領域
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
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