MGST1 Antibody - #DF4161
| 製品: | MGST1 Antibody |
| カタログ: | DF4161 |
| タンパク質の説明: | Rabbit polyclonal antibody to MGST1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 18 KD; 18kD(Calculated). |
| ユニプロット: | P10620 |
| RRID: | AB_2836526 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4161, RRID:AB_2836526.
折りたたみ／展開
MGST1; Glutathione S transferase 12; GST12; MGST 1; MGST; MGST I; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I;
免疫原
- P10620 MGST1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10620 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S31 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| C50 | S-Nitrosylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot |
研究背景
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
Microsome. Mitochondrion outer membrane>Peripheral membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein.
Highly expressed in liver.
Homotrimer; The trimer binds only one molecule of glutathione.
Belongs to the MAPEG family.
研究領域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
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