NCR1 Antibody - #DF4220

(2)  
製品: NCR1 Antibody
カタログ: DF4220
タンパク質の説明: Rabbit polyclonal antibody to NCR1
アプリケーション: WB IF/ICC
反応性: Human
分子量: 40 KD; 34kD(Calculated).
ユニプロット: O76036
RRID: AB_2836571

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
NCR1 Antibody detects endogenous levels of total NCR1.
RRID:
AB_2836571
引用形式: Affinity Biosciences Cat# DF4220, RRID:AB_2836571.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Activating NK receptor NK p46; CD335; FLJ99094; hNKp46; Ly94; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog (activating NK receptor; NK p46); Lymphocyte antigen 94 homolog; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NCR1; NCT1; NCTR1_HUMAN; NK cell activating receptor; NK cell-activating receptor; NK-p46; NKp46;

免疫原

免疫原:
Uniprot:

O76036(NCTR1_HUMAN) >>Visit HPA database.

遺伝子(ID):
NCR1(9437)
発現特異性:
O76036 NCTR1_HUMAN:

Selectively expressed by both resting and activated NK cells.

タンパク質配列:
MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVKFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL

PTMs - O76036 基板として

Site PTM Type Enzyme
Y84 Phosphorylation
S90 Phosphorylation
T292 Phosphorylation

研究背景

機能:

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

PTMs:

N-glycosylated.

O-glycosylated.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Selectively expressed by both resting and activated NK cells.

サブユニット構造:

Interacts with CD247 and FCER1G.

タンパク質ファミリー:

Belongs to the natural cytotoxicity receptor (NCR) family.

研究領域

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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