製品: SEPT3 Antibody
カタログ: DF4241
タンパク質の説明: Rabbit polyclonal antibody to SEPT3
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 41 KD; 41kD(Calculated).
ユニプロット: Q9UH03
RRID: AB_2836592

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
クローナリティ:
Polyclonal
特異性:
SEPT3 Antibody detects endogenous levels of total SEPT3.
RRID:
AB_2836592
引用形式: Affinity Biosciences Cat# DF4241, RRID:AB_2836592.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

bK250D10.3; MGC133218; Neuronal specific septin 3; Neuronal-specific septin-3; OTTHUMP00000028742; SEP 3; SEP3; SEPT 3; sept3; SEPT3 protein; SEPT3_HUMAN; Septin3;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9UH03 SEPT3_HUMAN:

Brain-specific.

タンパク質配列:
MSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9UH03 基板として

Site PTM Type Enzyme
K30 Methylation
S70 Phosphorylation
S84 Phosphorylation
S87 Phosphorylation
S91 Phosphorylation
S92 Phosphorylation
K226 Acetylation
K226 Ubiquitination

研究背景

機能:

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

PTMs:

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).

細胞の位置付け:

Cytoplasm. Cytoplasm>Cytoskeleton. Cell junction>Synapse.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain-specific.

サブユニット構造:

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).

タンパク質ファミリー:

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

研究領域

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

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