PEX19 Antibody - #DF4281
| 製品: | PEX19 Antibody |
| カタログ: | DF4281 |
| タンパク質の説明: | Rabbit polyclonal antibody to PEX19 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Dog |
| 分子量: | 33 KD; 33kD(Calculated). |
| ユニプロット: | P40855 |
| RRID: | AB_2836632 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4281, RRID:AB_2836632.
折りたたみ／展開
33 kDa housekeeping protein; D1S2223E; HK33; Housekeeping gene 33kD; OK/SW-cl.22; PBD12A; Peroxin 19; Peroxin-19; Peroxisomal biogenesis factor 19; Peroxisomal farnesylated protein; PEX19; PEX19_HUMAN; PMP1; PMPI; PXF; PXMP1;
免疫原
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
- P40855 PEX19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P40855 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| T42 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| K245 | Ubiquitination | Uniprot |
研究背景
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Cytoplasm. Peroxisome membrane>Lipid-anchor>Cytoplasmic side.
Note: Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
Belongs to the peroxin-19 family.
研究領域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
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