PEBP1 Antibody - #DF4290
| 製品: | PEBP1 Antibody |
| カタログ: | DF4290 |
| タンパク質の説明: | Rabbit polyclonal antibody to PEBP1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 23 KD; 21kD(Calculated). |
| ユニプロット: | P30086 |
| RRID: | AB_2836641 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4290, RRID:AB_2836641.
折りたたみ／展開
Epididymis luminal protein 210; Epididymis secretory protein Li 34; Epididymis secretory protein Li 96; HCNP; HCNPpp; HEL 210; HEL S 34; HEL S 96; Hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; PBP; PEBP; PEBP 1; PEBP-1; Pebp1; PEBP1_HUMAN; Phosphatidylethanolamine binding protein; Phosphatidylethanolamine binding protein 1; Prostatic binding protein; Prostatic-binding protein; R kip; Raf kinase inhibitor protein; Raf kinase inhibitory protein; RKIP;
免疫原
- P30086 PEBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSGK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P30086 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| K39 | Acetylation | Uniprot | |
| T42 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| T51 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K62 | Acetylation | Uniprot | |
| Y64 | Phosphorylation | Uniprot | |
| T69 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K77 | Acetylation | Uniprot | |
| K80 | Acetylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| Y106 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| Y120 | Phosphorylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| R129 | Methylation | Uniprot | |
| K132 | Acetylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| S153 | Phosphorylation | P17252 (PRKCA) , Q05655 (PRKCD) , P05129 (PRKCG) , P05771 (PRKCB) , Q05513 (PRKCZ) | Uniprot |
| C168 | S-Nitrosylation | Uniprot | |
| Y169 | Phosphorylation | Uniprot | |
| Y176 | Phosphorylation | Uniprot | |
| K179 | Acetylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| Y181 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot |
研究背景
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
Cytoplasm.
Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
Belongs to the phosphatidylethanolamine-binding protein family.
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