SERPING1 Antibody - #DF4299
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4299, RRID:AB_2836650.
折りたたみ／展開
C1 esterase inhibitor; C1 Inh; C1 inhibiting factor; C1 inhibitor; C1-inhibiting factor; C1IN; C1Inh; C1NH; complement component 1 inhibitor; esterase inhibitor; HAE1; HAE2; IC1_HUMAN; Plasma protease C1 inhibitor; Serine (or cysteine) proteinase inhibitor clade G member 1; serine/cysteine proteinase inhibitor clade G member 1; Serpin G1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; SERPING1;
免疫原
- P05155 IC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P05155 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R4 | Methylation | Uniprot | |
| N25 | N-Glycosylation | Uniprot | |
| T47 | O-Glycosylation | Uniprot | |
| T48 | O-Glycosylation | Uniprot | |
| S64 | O-Glycosylation | Uniprot | |
| N69 | N-Glycosylation | Uniprot | |
| T71 | O-Glycosylation | Uniprot | |
| N81 | N-Glycosylation | Uniprot | |
| T83 | O-Glycosylation | Uniprot | |
| T88 | O-Glycosylation | Uniprot | |
| T92 | O-Glycosylation | Uniprot | |
| T96 | O-Glycosylation | Uniprot | |
| N238 | N-Glycosylation | Uniprot | |
| N253 | N-Glycosylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| K316 | Acetylation | Uniprot | |
| K321 | Acetylation | Uniprot | |
| N352 | N-Glycosylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot |
研究背景
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
Can be proteolytically cleaved by E.coli stcE.
Secreted.
Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1.
Belongs to the serpin family.
研究領域
· Human Diseases > Infectious diseases: Bacterial > Pertussis.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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