ZFYVE20 Antibody - #DF4373
| 製品: | ZFYVE20 Antibody |
| カタログ: | DF4373 |
| タンパク質の説明: | Rabbit polyclonal antibody to ZFYVE20 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 89 KD; 89kD(Calculated). |
| ユニプロット: | Q9H1K0 |
| RRID: | AB_2836661 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4373, RRID:AB_2836661.
折りたたみ／展開
110 kDa protein; FYVE finger containing Rab5 effector protein Rabenosyn 5; FYVE finger-containing Rab5 effector protein rabenosyn-5; Rabenosyn-5; RBNS5_HUMAN; Zfyve20; zinc finger FYVE domain containing 20; Zinc finger FYVE domain-containing protein 20;
免疫原
- Q9H1K0 RBNS5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVASLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVWSGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKEYNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPFEMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQKGGTD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H1K0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S217 | Phosphorylation | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| Y496 | Phosphorylation | Uniprot | |
| T501 | Phosphorylation | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| T588 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S684 | Phosphorylation | Uniprot | |
| K773 | Ubiquitination | Uniprot |
研究背景
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane.
Cell membrane>Lipid-anchor>Cytoplasmic side. Early endosome membrane>Lipid-anchor.
Note: Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.
Interacts with EHD1, RAB4A, RAB5A, RAB14, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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