RDX Antibody - #DF4376
| 製品: | RDX Antibody |
| カタログ: | DF4376 |
| タンパク質の説明: | Rabbit polyclonal antibody to RDX |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 69 KD; 69kD(Calculated). |
| ユニプロット: | P35241 |
| RRID: | AB_2836664 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4376, RRID:AB_2836664.
折りたたみ／展開
CB567; CG12537; DFNB24; ESP10; Hh-induced MATH and BTB domain-containing protein; HIB; Moesin-B; Protein roadkill; RADI_HUMAN; Radixin; RDX;
免疫原
- P35241 RADI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35241 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Ubiquitination | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K79 | Acetylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| Y134 | Phosphorylation | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| R151 | Methylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| K253 | Acetylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K258 | Acetylation | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K262 | Acetylation | Uniprot | |
| K262 | Sumoylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K263 | Acetylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| Y270 | Phosphorylation | Uniprot | |
| R273 | Methylation | Uniprot | |
| Y291 | Phosphorylation | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| T299 | Phosphorylation | Uniprot | |
| K306 | Methylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| K344 | Acetylation | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| T542 | Phosphorylation | Uniprot | |
| K544 | Ubiquitination | Uniprot | |
| T545 | Phosphorylation | Uniprot | |
| K556 | Acetylation | Uniprot | |
| K556 | Ubiquitination | Uniprot | |
| Y562 | Phosphorylation | Uniprot | |
| T564 | Phosphorylation | O94804 (STK10) , P41279 (MAP3K8) , Q04759 (PRKCQ) , P25098 (GRK2) , O95819 (MAP4K4) , O75116 (ROCK2) , Q5S007 (LRRK2) , Q13464 (ROCK1) | Uniprot |
| T573 | Phosphorylation | Uniprot |
研究背景
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cleavage furrow. Cell projection>Microvillus.
Note: Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain). Interacts with SPN and CD44 (By similarity).
The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity).
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
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