PPP1R3A Antibody - #DF4345
| 製品: | PPP1R3A Antibody |
| カタログ: | DF4345 |
| タンパク質の説明: | Rabbit polyclonal antibody to PPP1R3A |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 分子量: | 140 KD; 126kD(Calculated). |
| ユニプロット: | Q16821 |
| RRID: | AB_2836713 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4345, RRID:AB_2836713.
折りたたみ／展開
Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle; Glycogen associated regulatory subunit of protein phosphatase 1; GM; PP1G; PPP1R3; PPP1R3A; PPR3A_HUMAN; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase 1 glycogen-targeting subunit, muscle; Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 regulatory subunit GM; protein phosphatase 1, regulatory (inhibitor) subunit 3A; Protein phosphatase 1, regulatory subunit 3; Protein phosphatase type-1 glycogen targeting subunit; RG1; Serine /threonine specific protein phosphatase; Type 1 protein phosphatase skeletal muscle glycogen targeting subunit;
免疫原
- Q16821 PPR3A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQPSRRGSDSSEDIYLDTPSSGTRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKEDLMQQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVPNSCDGETDQFSFKIVLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKEQEPEPVKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNFENPKNTDTYIPTIICSHEDKEDLEASNRNVKDVNREHDEHNEKELELMINQHLIRTRSTASRDERNTFSTDPVNFPNKAEGLEKKQIHGEICTDLFQRSLSPSSSAESSVKGDFYCNEKYSSGDDCTHQPSEETTSNMGEIKPSLGDTSSDELVQLHTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKKHEGGAKNIEVKDLGCLRRDFHSDTSACLKESTEEGSSKEDYYGNGKDDEEQRIYLGVNEKQRKNFQTILHDQERKMGNPKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPRTNLSWEEAVLTPEHHHLTSEGSALGGITGQVCSSRTGNVLRNDYLFQVEEKSGGINSEDQDNSPQHKQSWNVLESQGKSRENKTNITEHIKGQTDCEDVWGKRDNTRSLKATTEELFTCQETVCCELSSLADHGITEKAEAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRNDDSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKEETMSMYNPRKTHDREKCGTGNITSVEESSWVITEYQKATSKLDLQLGMLPTDKTVFSENRDLRQVQELSKKTDSDAIVHSAFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENAVTTMASQPISTKSENICNSTREIQGIEKHPYPESKPEEVSRSSGIVTSGSRKERCIGQIFQTEEYSVEKSLGPMILINKPLENMEEARHENEGLVSSGQSLYTSGEKESDSSASTSLPVEESQAQGNESLFSKYTNSKIPYFLLFLIFLITVYHYDLMIGLTFYVLSLSWLSWEEGRQKESVKKK
PTMs - Q16821 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | P51812 (RPS6KA3) | Uniprot |
| S48 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | P51812 (RPS6KA3) | Uniprot |
| S332 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| T735 | Phosphorylation | Uniprot | |
| T736 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| T759 | Phosphorylation | Uniprot | |
| T822 | Phosphorylation | Uniprot | |
| S824 | Phosphorylation | Uniprot | |
| Y826 | Phosphorylation | Uniprot | |
| T939 | Phosphorylation | Uniprot | |
| T940 | Phosphorylation | Uniprot | |
| S1066 | Phosphorylation | Uniprot | |
| S1069 | Phosphorylation | Uniprot |
研究背景
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).
Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.
Membrane>Single-pass membrane protein.
Skeletal muscle and heart.
Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.
The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
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