RAP1GAP Antibody - #DF4383
(1)
(6)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4383, RRID:AB_2836738.
折りたたみ／展開
KIAA0474; Rap1 GTPase activating protein 1; RAP1 GTPase activating protein; Rap1 GTPase-activating protein 1; RAP1GA1; Rap1ga1 protein; Rap1GAP; Rap1GAP1; RAP1GAPII; RAPGAP; RPGP1_HUMAN;
免疫原
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
- P47736 RPGP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASSFASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKLGDPACPEIKIQLEASEQHMPQLGC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P47736 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y27 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K262 | Acetylation | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| K378 | Acetylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | P06493 (CDK1) | Uniprot |
| T486 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S495 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S515 | Phosphorylation | Uniprot | |
| T522 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S541 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| T547 | Phosphorylation | Uniprot | |
| T548 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot |
研究背景
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Golgi apparatus membrane>Peripheral membrane protein.
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
Homodimer and heterodimer with RAP1B.
研究領域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
参考文献
Application: WB Species: Mouse Sample: skin tissues
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