RASSF6 Antibody - #DF4385
| 製品: | RASSF6 Antibody |
| カタログ: | DF4385 |
| タンパク質の説明: | Rabbit polyclonal antibody to RASSF6 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 45 KD; 43kD(Calculated). |
| ユニプロット: | Q6ZTQ3 |
| RRID: | AB_2836740 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4385, RRID:AB_2836740.
折りたたみ／展開
Putative RAS binding protein; Ras association (RalGDS/AF 6) domain family 6; Ras association (RalGDS/AF 6) domain family member 6; Ras association domain containing protein 6; Ras association domain family member 6;
免疫原
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
- Q6ZTQ3 RASF6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLWEETGAAPAPARASDLPYRISSDHLKKEEKMTMMAHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFWGVKRPIQLKIQDEKPFSSFTSMKSSDVFSSKGMTRWGEFDDLYRISELDRTQIPMSEKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALVRKRMKPLMMDRKERQKNRASINGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTETTV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6ZTQ3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K170 | Ubiquitination | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot |
研究背景
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse, but not in human. Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported.
研究領域
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species. (View pathway)
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