RGS7 Antibody - #DF4418
| 製品: | RGS7 Antibody |
| カタログ: | DF4418 |
| タンパク質の説明: | Rabbit polyclonal antibody to RGS7 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 65 KD; 58kD(Calculated). |
| ユニプロット: | P49802 |
| RRID: | AB_2836773 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4418, RRID:AB_2836773.
折りたたみ／展開
OTTHUMP00000037994; Regulator of G protein signalling 7; Regulator of G-protein signaling 7; Regulator of G-protein signaling RGS7; Regulator of G-protein signalling 7;
免疫原
- P49802 RGS7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49802 基板として
研究背景
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
Palmitoylated.
Ubiquitinated, leading to rapid proteasomal degradation.
Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.
Cytoplasm>Cytosol. Cytoplasm. Cell membrane. Membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264).
Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Interacts (phosphorylated form) with 14-3-3 protein YWHAQ. Interacts with SNAPIN. Interacts with GNAI1. Interacts with GNAO1, GNAI3 and GNAZ (By similarity).
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